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Specialized Investigation

Custom Scientific Services: Drawing on our extensive expertise in assay development, validation and regulatory requirements we work with our customers to optimize assays to answer product specific questions. The technical capabilities we utilize for these projects include:


  • Cell Culture
    • Primary human and other mammalian cells
    • Established cell lines
    • 3-D tissue constructs
    • Ex vivo organ cultures
  • Cell proliferation and cytotoxicity evaluation using viability dyes and functional endpoints
  • Spectrophotometric (colormetric), fluormetric and luminescence endpoints in 96 well plate format
  • Cytokine endpoints (e.g. IL-1?, TNF?, IL-6, IL-8, etc.)
  • ELISA techniques, typically used to evaluate induction, expression or production of functional proteins
  • Phototoxicity screening and photo-protection studies
  • Real time cell respiration studies using the Cytosensor™ Microphysiometer
  • Percutaneous absorption studies utilizing PermeGear flow-through diffusion cells
  • Genotoxicity assessment in human 3-D skin constructs
  • Screening for modulators of human melanogenesis

Technical Services

  • Bioassay development and protocol optimization services
  • Methods development, pre-validation and validation services including validation submissions
  • Training services (technical and compliance)
    • Vendor audit services (technical and compliance)

To discuss how IIVS’s technical capabilities and specialized knowledge can help meet your needs, please contact us.