The predictive capacity of the 3T3 Neutral Red Uptake assay to identify substances LD with acute oral LD50 50 > kg> 2000 mg/kg poster presented at IUTOX
Published: August 4th, 2010 | Category: Whats New
The purpose of this validation study is to assess the capacity of the 3T3/NRU cytotoxicity assay to give a simple yes or no answer in order to discriminate between toxic/hazardous (LD50 < 2000 mg/kg) and not classified (LD50 >2000 mg/kg) substances....
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COLIPA validation of the Reconstructed Human Skin Micronucleus Assay (RSMN): A novell micronucleus assay in a 3D human skin model
Published: October 5th, 2009 | Category: IIVS Publications
Current mammalian cell in vitro genotoxicity assays induce a high level of false positive results leading to a large number of costly and time consuming followup in vivo genotoxicity studies. As of March 2009, the 7th Amendment to the EU Cosmetics Directive prohibits the use of in vivo genotoxicity tests in safety assessments for cosmetics, greatly...
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RESULTS OF A TWO LABORATORY REPRODUCIBILITY STUDY USING A HARMONIZED BOVINE CORNEAL OPACITY AND PERMEABILITY (BCOP) PROTOCOL
Published: October 5th, 2009 | Category: IIVS Publications
The Bovine Corneal Opacity and Permeability assay (BCOP), an internationally recognized alternative to the Draize eye irritation test, uses excised bovine corneas to predict ocular irritation. Originally developed by Gautheron (1992) and utilizing the irritation class prediction established by Sina (1994), BCOP has been used independently at MB Res...
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UK Increases Funding of Alternatives
Published: December 11th, 2007 | Category: Press Releases
Source: CORDIS - Community Research & Development Information Service
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The UK has announced that it is to double funding for research aimed at reducing and replacing the use of animals in experiments......
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ESAC has endorsed 5 new alternative testing methods
Published: June 6th, 2007 | Category: Non-IIVS Publications
Source: European Centre for the Validation of Alternative Methods
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The ECVAM Scientific Advisory Committee (ESAC) has announced the validation of five new in vitro tests. The tests include EpiDerm® and Bovine Corneal Opacity and Permeability (BCOP).
For more information click the Read More below. In the new window select Publications which is located in the menu at the top of the webs...
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IIVS newsletter - July 2006
Published: August 21st, 2006 | Category: IIVS Publications
Source: IIVS
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IIVS Newsletter November 2005
Published: November 30th, 2005 | Category: IIVS Publications
Source: IIVS
IIVS progress on optimization of Alternative Tests,
ICCVAM Expert Panel Reviews BRD Addenda,
Standards for In Vitro Tests, and more.
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The EpiOcular model – protocol, performance and experience
Published: August 26th, 2005 | Category: IIVS Publications
Source: Practical Training Workshop on In Vitro Eye Irritation Methods, August 26, 2006, Berlin, Germany
Practical Training Workshop on In Vitro Eye Irritation Methods
Co-sponsored by:
Institute for In Vitro Sciences, IIVS (Gaithersburg, USA)
Beiersdorf AG (Hamburg, Germany)
BfR-ZEBET (Berlin, Germany)
SCOPE: The Workshop aims at practical training in most frequently used in vitro methods for
prediction of eye irritation potential. Primary focus...
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REPORT FROM AN IN VITRO DERMAL ABSORPTION ASSAY WORKSHOP
Published: August 21st, 2005 | Category: IIVS Publications
Source: Presented at the 5th World Congress on Alternatives and Animal Use in Life Sciences, Berlin, Germany, August 21-25.
The Institute for In Vitro Sciences (IIVS), Gaithersburg, Maryland, USA, hosted a workshop on in vitro
percutaneous absorption (PA) methods for a small group of international stakeholders in July 2005. The
purpose of the workshop was to provide a forum where stakeholders and method experts could come
together to discuss the various OECD-approved...
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Addressing Animal Testing Concerns: A Novel Micronucleus Assay Using The Human 3-D Skin Model, EpiDerm™
Published: August 21st, 2005 | Category: IIVS Publications
Source: Presented at the 5th World Congress on Alternatives & Animal Use in the Life Sciences, Berlin Germany, Aug. 21-26, 2005
To meet the requirements of the EU 7th Amendment to the Cosmetics Directive, manufacturers of cosmetics
products will need to ascertain the safety of ingredients using non-animal methods. Starting in 2009, in vivo
genotoxicity tests for cosmetic ingredients will not be allowed. Skin is one of the target areas of interest for
many cosmetic produc...
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Applying Good Laboratory Practices (GLPs) to In Vitro Studies: One Laboratory's Perspective
Published: August 21st, 2005 | Category: IIVS Publications
Source: Presented at the 5th World Congress on Alternatives and Animal Use in the Life Sciences, Berlin, Germany, August 21-26, 2005
The steady increase in industry use and regulatory acceptance of in vitro test methods has resulted in an increased need to apply Good Laboratory Practice (GLP) regulations to these systems. The original GLP regulations, developed to address the conduct of animal studies, are concerned with many special conditions that apply to animal housing and c...
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IIVS Newsletter August 2005
Published: August 15th, 2005 | Category: IIVS Publications
Source: Institute for In Vitro Science, Volume 4; Issue 1
IIVS news on 1) In vitro eye irritation testing of antimicrobial products and the EPA, 2) ECVAM eye irritation expert meeting, 3) ICCVAM project on severe eye irritation, 5)World Congress on Alternatives & Animal Use in the Life Sciences Practical Training Workshop on In Vitro eye Irritation Methods and more!...
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Prediction of ocular irritancy of prototype shampoo formulations by the isolated rabbit eye (IRE) test and bovine corneal opacity and permeability (BCOP) assay.
Published: January 1st, 2001 | Category: IIVS Publications
Source: Reprinted from Toxicology In Vitro, Vol. 15, p. 95-103, 2001, with permission from elsevier Science. (ScienceDirectTM http://www. sciencedirect.com)
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Assessment of the Cytosensor Microphysiometer Assay in the COLIPA In Vitro Eye Irritation Validation Study.
Published: January 1st, 1999 | Category: IIVS Publications
Source: Reprinted from Toxicology In Vitro, Vol. 13, pp. 313-323, 1999, with permission from Elsevier Science. (ScienceDirectTM http://www.sciencedirect.com)
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The ECVAM International Validation Study on In Vitro Tests for Skin corrosivity. 2. Results and Evaluation by the Management Team
Published: January 1st, 1998 | Category: IIVS Publications
Source: Reprinted from Toxicology In Vitro, Vol. 12, pp. 483-524, 1998, with permission from Elsevier Science (ScienceDirect TM http://www.sciencedirect.com)
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A Summary Report of the COLIPA International Validation Study on Alternatives to the Draize Rabbit Eye Test
Published: January 1st, 1997 | Category: IIVS Publications
Source: Reprinted from Toxicology In Vitro, Vol. 11, pp. 141-179, 1997, with permission from Elsevier Science. (SciencedirectTM http://www.sciencedirect.com)
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Development and Validation of Non-animal Tests and Testing Stragegies: the Identification of a Coordinated Response to the Challenge and Opportunity Presented by the Sixth Amendment to the Cosmetic Directive
Published: January 19th, 1995 | Category: IIVS Publications
Source: ATLA 23, 398-409
This is a report of the seventh of a series of workshops organised by the European Center for the Validation of Alterntive Methods (ECVAM). This particular workshop was a joint initiative of ECVAM and the Cosnumer Policy Servie (CPS). ...
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