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BOVINE CORNEAL OPACITY AND PERMEABILITY ASSAY - RESULTS OF A TWO LABORATORY REPRODUCIBILITY STUDY
Published: March 8th, 2010 | Category: IIVS Publications
Source: SOT
The Bovine Corneal Opacity and Permeability assay (BCOP), an internationally recognized alternative to the Draize eye irritation test, uses excised bovine corneas to predict ocular irritation. Originally developed by Gautheron (1992) and utilizing the irritation class prediction established by Sina (1994), BCOP has been used independently at MB Res...
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ICCVAM Issues Recommendations on In Vitro Pyrogenicity Test Methods
Published: December 8th, 2008 | Category: Public Policy
NICEATM announces availability of the ICCVAM Test Method Evaluation Report: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products (NIH Publication Number 08-6392) and Final Background Review Document: Validation Status of Five In Vitro Test Methods Proposed for Assessing ...
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Experiences In The Development And Utilization Of An In Vitro Safety Testing Program For Hair Conditioners
Published: September 20th, 2007 | Category: IIVS Publications
Source: 6th World Congress on Alternatives and Animal Use in the Life Sciences, Tokyo, Japan 2007
Assuring the safety of cosmetics and personal care products without testing in animals has long been the goal of many international companies. This concern has become even more important with the requirement of the Seventh Amendment to the Cosmetics Directive that after 2009 animal testing cannot be used to assess the eye or skin irritation potenti...
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Estimating Systemic Toxicity In Vitro Using An Adenosine Triphosphate Cytotoxicity (ATP) Assay In Normal Human Epidermal Keratinocytes
Published: September 20th, 2007 | Category: IIVS Publications
Source: 6th World Congress on Alternatives and Animal Use in the Life Sciences, Tokyo, Japan 2007
Ekwall et al. (ATLA 17:83-100, 1989) have proposed that ˜80% of chemical-induced systemic toxicity is the result of disruption of basic cellular processes common to most cell types in the body, and that systemic toxicity for many chemicals could be estimated in in vitro cultures. Strickland et al (The Toxicologist, Abs#761, 2003) reported on a join...
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ESAC has endorsed 5 new alternative testing methods
Published: June 6th, 2007 | Category: Non-IIVS Publications
Source: European Centre for the Validation of Alternative Methods
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The ECVAM Scientific Advisory Committee (ESAC) has announced the validation of five new in vitro tests. The tests include EpiDerm® and Bovine Corneal Opacity and Permeability (BCOP).
For more information click the Read More below. In the new window select Publications which is located in the menu at the top of the webs...
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IIVS Newsletter November 2005
Published: November 30th, 2005 | Category: IIVS Publications
Source: IIVS
IIVS progress on optimization of Alternative Tests,
ICCVAM Expert Panel Reviews BRD Addenda,
Standards for In Vitro Tests, and more.
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The EpiOcular model – protocol, performance and experience
Published: August 26th, 2005 | Category: IIVS Publications
Source: Practical Training Workshop on In Vitro Eye Irritation Methods, August 26, 2006, Berlin, Germany
Practical Training Workshop on In Vitro Eye Irritation Methods
Co-sponsored by:
Institute for In Vitro Sciences, IIVS (Gaithersburg, USA)
Beiersdorf AG (Hamburg, Germany)
BfR-ZEBET (Berlin, Germany)
SCOPE: The Workshop aims at practical training in most frequently used in vitro methods for
prediction of eye irritation potential. Primary focus...
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REPORT FROM AN IN VITRO DERMAL ABSORPTION ASSAY WORKSHOP
Published: August 21st, 2005 | Category: IIVS Publications
Source: Presented at the 5th World Congress on Alternatives and Animal Use in Life Sciences, Berlin, Germany, August 21-25.
The Institute for In Vitro Sciences (IIVS), Gaithersburg, Maryland, USA, hosted a workshop on in vitro
percutaneous absorption (PA) methods for a small group of international stakeholders in July 2005. The
purpose of the workshop was to provide a forum where stakeholders and method experts could come
together to discuss the various OECD-approved...
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Applying Good Laboratory Practices (GLPs) to In Vitro Studies: One Laboratory's Perspective
Published: August 21st, 2005 | Category: IIVS Publications
Source: Presented at the 5th World Congress on Alternatives and Animal Use in the Life Sciences, Berlin, Germany, August 21-26, 2005
The steady increase in industry use and regulatory acceptance of in vitro test methods has resulted in an increased need to apply Good Laboratory Practice (GLP) regulations to these systems. The original GLP regulations, developed to address the conduct of animal studies, are concerned with many special conditions that apply to animal housing and c...
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SC JOHNSON’S CONSUMER PRODUCT HAZARD EVALUATION PROGRAM USING ALTERNATIVE ASSAYS
Published: August 20th, 2005 | Category: IIVS Publications
SC Johnson is a global consumer products company that manufactures a variety of household products that must be evaluated for human health hazards. For over 10 years, SC Johnson has conducted the necessary research to spearhead efforts to reduce the use of animals in the hazard assessment process. We routinely use alternative approaches such as the...
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IIVS Newsletter August 2005
Published: August 15th, 2005 | Category: IIVS Publications
Source: Institute for In Vitro Science, Volume 4; Issue 1
IIVS news on 1) In vitro eye irritation testing of antimicrobial products and the EPA, 2) ECVAM eye irritation expert meeting, 3) ICCVAM project on severe eye irritation, 5)World Congress on Alternatives & Animal Use in the Life Sciences Practical Training Workshop on In Vitro eye Irritation Methods and more!...
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MANAGING TOXIC SYNERGISM IN HYPOCHLORITE-CONTAINING CLEANERS USING THE BOVINE CORNEAL OPACITY AND PERMEABILITY (BCOP) ASSAY, Part II
Published: March 12th, 2004 | Category: IIVS Publications
Consumers continue to seek products that will both clean and combat mold and mildew stains on various surfaces in the home. Such products are commonly formulated as alkaline hypochlorite and surfactant-containing aqueous solutions and usually have
significant ocular irritation potential. Previous studies have shown the applicability of the BCOP As...
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Prediction of ocular irritancy of prototype shampoo formulations by the isolated rabbit eye (IRE) test and bovine corneal opacity and permeability (BCOP) assay.
Published: January 1st, 2001 | Category: IIVS Publications
Source: Reprinted from Toxicology In Vitro, Vol. 15, p. 95-103, 2001, with permission from elsevier Science. (ScienceDirectTM http://www. sciencedirect.com)
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