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DEVELOPMENT OF A BARRIER-COMPROMISED HUMAN SKIN MODEL FOR IN VITRO PERCUTANEOUS PENETRATION STUDIES
Published: March 5th, 2010 | Category: IIVS Publications
Procedures for preparing barrier-compromised human donor skin for use in in vitro percutaneous penetration studies as a model of damaged or disease-state skin, where a reduced barrier function due to loss or abnormal development of the stratum corneum is characteristic, were developed. Two methods for disrupting the stratum corneum were evaluated, ...
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IIVS newsletter - July 2006
Published: August 21st, 2006 | Category: IIVS Publications
Source: IIVS
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IIVS Newsletter November 2005
Published: November 30th, 2005 | Category: IIVS Publications
Source: IIVS
IIVS progress on optimization of Alternative Tests,
ICCVAM Expert Panel Reviews BRD Addenda,
Standards for In Vitro Tests, and more.
...
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REPORT FROM AN IN VITRO DERMAL ABSORPTION ASSAY WORKSHOP
Published: August 21st, 2005 | Category: IIVS Publications
Source: Presented at the 5th World Congress on Alternatives and Animal Use in Life Sciences, Berlin, Germany, August 21-25.
The Institute for In Vitro Sciences (IIVS), Gaithersburg, Maryland, USA, hosted a workshop on in vitro
percutaneous absorption (PA) methods for a small group of international stakeholders in July 2005. The
purpose of the workshop was to provide a forum where stakeholders and method experts could come
together to discuss the various OECD-approved...
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PERFORMANCE STANDARDS FOR IN VITRO STUDIES
Published: August 21st, 2005 | Category: IIVS Publications
Source: Presented at the 5th World Congress on Alternatives and Animal Use in the Life Sciences, Berlin, Germany, August 21-26, 2005
In vitro test systems offer the potential for high consistency and resulting high predictive capacity. This promise comes from the ability to control many of the independent variables that can lead to the variability of responses in vivo. Furthermore, most of the in vitro tests currently employed, have undergone some level of formal validation or a...
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THE IMPACT OF ETHANOL ON THE IN VITRO SKIN PENETRATION RATES OF CAFFEINE IN ENGINEERED SKIN CONSTRUCTS.
Published: March 1st, 2004 | Category: IIVS Publications
Source: Presented at Society of Toxicology 2004, March, 2003, Baltimore, MD,
The reference material, caffeine (prepared in ethanol), was evaluated in 3 in vitro models to compare the rates of skin
penetration in each of the models. The models were human donor skin, an engineered skin construct (MatTek Corporation,
Model EPI-606X) and slaughterhouse-derived pig skin. The tissues were mounted in flow-through diffusion cells...
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In Vitro Percutaneous Absorption In The MatTek EPI-606X Skin Construct And Human Skin
Published: April 30th, 2003 | Category: IIVS Publications
Source: Presented at the International Investigative Dermatology 2003
The rates of absorption of chemicals in human skin can be modeled in the in vitro percutaneous absorption assay. Moreover, the impact of various vehicles on the permeation rates of chemicals can also be evaluated. Benzoic acid (BA) was prepared in two vehicles (acetone and petrolatum) and was tested in duplicate trials in an engineered human skin c...
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