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ESAC has endorsed 5 new alternative testing methods
Published: June 6th, 2007 | Category: Non-IIVS Publications
Source: European Centre for the Validation of Alternative Methods
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The ECVAM Scientific Advisory Committee (ESAC) has announced the validation of five new in vitro tests. The tests include EpiDermŽ and Bovine Corneal Opacity and Permeability (BCOP).
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Applying Good Laboratory Practices (GLPs) to In Vitro Studies: One Laboratory's Perspective
Published: August 21st, 2005 | Category: IIVS Publications
Source: Presented at the 5th World Congress on Alternatives and Animal Use in the Life Sciences, Berlin, Germany, August 21-26, 2005
The steady increase in industry use and regulatory acceptance of in vitro test methods has resulted in an increased need to apply Good Laboratory Practice (GLP) regulations to these systems. The original GLP regulations, developed to address the conduct of animal studies, are concerned with many special conditions that apply to animal housing and c...
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IIVS Newsletter August 2005
Published: August 15th, 2005 | Category: IIVS Publications
Source: Institute for In Vitro Science, Volume 4; Issue 1
IIVS news on 1) In vitro eye irritation testing of antimicrobial products and the EPA, 2) ECVAM eye irritation expert meeting, 3) ICCVAM project on severe eye irritation, 5)World Congress on Alternatives & Animal Use in the Life Sciences Practical Training Workshop on In Vitro eye Irritation Methods and more!...
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A Prevalidation Study on In Vitro Skin Corrosivity Testing
Published: January 1st, 2005 | Category: IIVS Publications
Source: ATLA 23, 219-255
The Report and Recommendation of ECVAM Workshop 6....
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Ocular Safety: A Silent (In Vitro) Success Story
Published: January 1st, 2002 | Category: IIVS Publications
Source: ATLA, 30, suppliment 2, 69-74, 2002
— Ocular irritation testing has been one of the animal test methods most criticised by animal welfare advocates. Additional criticism has arisen from within the scientific community, based on the variability of the animal test results and the questionable relevance of the extremely high dose levels employed. As a result, the Draize eye irritat...
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A prevalidation study on in vitro tests for acute skin irritation: results and evaluation by the Management Team
Published: January 1st, 2001 | Category: IIVS Publications
Source: Reprinted from Toxicology In Vitro, Vol. 15, pp. 57-93, 2001, with permission from Elsevier Science (ScienceDirect TM http://www.sciencedirect.com)
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The ECVAM International Validation Study on In Vitro Tests for Skin corrosivity. 2. Results and Evaluation by the Management Team
Published: January 1st, 1998 | Category: IIVS Publications
Source: Reprinted from Toxicology In Vitro, Vol. 12, pp. 483-524, 1998, with permission from Elsevier Science (ScienceDirect TM http://www.sciencedirect.com)
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The Validation of Toxicological Prediction Models
Published: January 19th, 1997 | Category: IIVS Publications
Source: ATLA 25, 505-516
An alternative method is shown to consist of two parts; The test system itself; and a prediction model for onverting in vitro endpoints into predictions of in vivo toxicity. For the alternative method to be relevant and reliable, it is important that its prediction model component is of high predictive power and is sufficiently robust against sourc...
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Development and Validation of Non-animal Tests and Testing Stragegies: the Identification of a Coordinated Response to the Challenge and Opportunity Presented by the Sixth Amendment to the Cosmetic Directive
Published: January 19th, 1995 | Category: IIVS Publications
Source: ATLA 23, 398-409
This is a report of the seventh of a series of workshops organised by the European Center for the Validation of Alterntive Methods (ECVAM). This particular workshop was a joint initiative of ECVAM and the Cosnumer Policy Servie (CPS). ...
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The Role of Prevalidation in the Development, Validation and Acceptance of Alternative Methods
Published: January 1st, 1995 | Category: IIVS Publications
Source: ATLA 23, 211-217, 1995
Experience has shown that the outcome of large and expensive validation studies on alternative methods can be compromised if their managers do not insist that optimised test protocols and proof of their performance are submitted ,i>before the start of the formal validation study. One way for the sponsors of validation studies to confirm both th...
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