IN VITRO ASSESSMENT OF PERSONAL CARE PRODUCTS FOR VAGINAL IRRITATION USING 3D TISSUE CONSTRUCTS
Published: March 5th, 2010 | Category: IIVS Publications
Three dimensional (3D) human vaginal-ectocervical tissue constructs may be a relevant in vitro model to rapidly screen for vaginal mucosal irritation potential of raw materials and final formulations. Here we report results from a study with an in vitro vaginal tissue construct (EpiVaginalTM from Mattek Corporation, USA), used to predict irritation...
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COLIPA validation of the Reconstructed Human Skin Micronucleus Assay (RSMN): A novell micronucleus assay in a 3D human skin model
Published: October 5th, 2009 | Category: IIVS Publications
Current mammalian cell in vitro genotoxicity assays induce a high level of false positive results leading to a large number of costly and time consuming followup in vivo genotoxicity studies. As of March 2009, the 7th Amendment to the EU Cosmetics Directive prohibits the use of in vivo genotoxicity tests in safety assessments for cosmetics, greatly...
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Critical Factors Impacting Interlaboratory Transferrability of the Mouse Embryonic Stem Cell Test
Published: October 5th, 2009 | Category: IIVS Publications
The EST has been formally validated by the European Centre for the Validation of Alternative Methods (ECVAM) as an acceptable in vitro embryotoxicity assay. During the prevalidation trials, the technology was easily transferred between laboratories in the European Union. However, transferring the assay to the Institute for In Vitro Sciences (IIVS) ...
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Reference Laboratories Can Make Validation More Efficient
Published: October 5th, 2009 | Category: IIVS Publications
The validation of in vitro methods is a lengthy process encompassing multiple phases. It progresses from initial test development, through test optimization and prevalidation, to a formal validation assessment, and eventually to regulatory acceptance. Each of these phases relies heavily on the outcome of laboratory activities - even the regulatory ...
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Further development of the EpiDerm 3D reconstructed human skin micronucleus (RSMN) assay
Published: March 27th, 2009 | Category: IIVS Publications
Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis
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The upcoming ban on testing of cosmetics in animals by the European Union 7th Amendment to the Cosmetics Directive will require genotoxicity safety assessments of cosmetics ingredients and final formulations to be based primarily on in vitro genotoxicity tests. The current in vitro test battery produces an unacceptably high rate of false positives,...
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Poster on IIVS to be Presented this Weekend at Linz Conference
Published: September 18th, 2008 | Category: IIVS Publications
A poster explaining the services provided by IIVS and highlighting how IIVS contributes to the global alternatives testing community will be presented this weekend at the 15th Congress on Alternatives to Animal Testing in Linz, Austria. ...
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Global Animal Use Estimates for 2005 Published in ATLA
Published: August 18th, 2008 | Category: Non-IIVS Publications
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The British Union for the Abolition of Vivisection (BUAV) and the Dr Hadwen Trust for Humane Research have partnered to compile the first worldwide estimate on animal use in research. The paper, published in the journal ATLA, details how the estimated 115 million animals used in 2005 was derived. Many countries do not record the number of animals u...
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The Nordic Prize for Alternatives to Animal Experiments 2007 is awarded to Dr Anna Forsby, University of Stockholm
Published: November 21st, 2007 | Category: Press Releases
Dr. Anna Forsby and her co-workers at the University of Stockholm are using novel nerve cell models to replace animal experiments in the areas of acute toxicity, eye irritation, and diabetes research. Dr. Forsby has recognised the possibilities of using cultured nerve cells to improve the research and add important information to other, existing in...
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Dr. Rodger Curren receives the 2007 RUSSELL and BURCH Award
Published: August 31st, 2007 | Category: Press Releases
Source: The Humane Society Legislative Fund
The HSUS bestows the Russell and Burch Award at the World Congresses on Alternatives and Animal Use in the Life Sciences. The 6th World Congress was held in Tokyo, Japan in August. Dr. Curren was presented with the 2007 Russell and Burch Award by Marty Stevens from the HSUS. For more information:...
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Toxicity Testing in the 21st Century
Published: July 31st, 2007 | Category: Non-IIVS Publications
Source: The National Academies
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Read the report summary provided by The National Academies....
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Review of the Draft NICEATM-ICCVAM Five-Year Plan By the SACATM Working Group
Published: July 13th, 2007 | Category: Public Policy
(best viewed through Internet Explorer)...
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Summary of ICCVAM Town Meeting to review 5 Year Plan
Published: July 9th, 2007 | Category: Public Policy
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ESAC has endorsed 5 new alternative testing methods
Published: June 6th, 2007 | Category: Non-IIVS Publications
Source: European Centre for the Validation of Alternative Methods
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The ECVAM Scientific Advisory Committee (ESAC) has announced the validation of five new in vitro tests. The tests include EpiDerm® and Bovine Corneal Opacity and Permeability (BCOP).
For more information click the Read More below. In the new window select Publications which is located in the menu at the top of the webs...
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Dr. Rodger Curren receives the 2007 Bjorn Ekwall Memorial Award
Published: May 21st, 2007 | Category: Press Releases
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Congratulations to Dr. Curren, this years recipient of The Björn Ekwall Memorial Award....
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New REACH regulation
Published: February 6th, 2007 | Category: Press Releases
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Amendments to the REACH directive were published in the Official Journal of the European Union on December 30, 2006.
Article (1) states:
“This Regulation should ensure a high level of protection of human health and the environment as well as the free movement of substances, on their own, in preparations and in articles, while enhancing co...
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The EpiOcular model – protocol, performance and experience
Published: August 26th, 2005 | Category: IIVS Publications
Source: Practical Training Workshop on In Vitro Eye Irritation Methods, August 26, 2006, Berlin, Germany
Practical Training Workshop on In Vitro Eye Irritation Methods
Co-sponsored by:
Institute for In Vitro Sciences, IIVS (Gaithersburg, USA)
Beiersdorf AG (Hamburg, Germany)
BfR-ZEBET (Berlin, Germany)
SCOPE: The Workshop aims at practical training in most frequently used in vitro methods for
prediction of eye irritation potential. Primary focus...
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Applying Good Laboratory Practices (GLPs) to In Vitro Studies: One Laboratory's Perspective
Published: August 21st, 2005 | Category: IIVS Publications
Source: Presented at the 5th World Congress on Alternatives and Animal Use in the Life Sciences, Berlin, Germany, August 21-26, 2005
The steady increase in industry use and regulatory acceptance of in vitro test methods has resulted in an increased need to apply Good Laboratory Practice (GLP) regulations to these systems. The original GLP regulations, developed to address the conduct of animal studies, are concerned with many special conditions that apply to animal housing and c...
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MANAGING TOXIC SYNERGISM IN HYPOCHLORITE-CONTAINING CLEANERS USING THE BOVINE CORNEAL OPACITY AND PERMEABILITY (BCOP) ASSAY, Part II
Published: March 12th, 2004 | Category: IIVS Publications
Consumers continue to seek products that will both clean and combat mold and mildew stains on various surfaces in the home. Such products are commonly formulated as alkaline hypochlorite and surfactant-containing aqueous solutions and usually have
significant ocular irritation potential. Previous studies have shown the applicability of the BCOP As...
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THE IMPACT OF ETHANOL ON THE IN VITRO SKIN PENETRATION RATES OF CAFFEINE IN ENGINEERED SKIN CONSTRUCTS.
Published: March 1st, 2004 | Category: IIVS Publications
Source: Presented at Society of Toxicology 2004, March, 2003, Baltimore, MD,
The reference material, caffeine (prepared in ethanol), was evaluated in 3 in vitro models to compare the rates of skin
penetration in each of the models. The models were human donor skin, an engineered skin construct (MatTek Corporation,
Model EPI-606X) and slaughterhouse-derived pig skin. The tissues were mounted in flow-through diffusion cells...
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A prevalidation study on in vitro tests for acute skin irritation: results and evaluation by the Management Team
Published: January 1st, 2001 | Category: IIVS Publications
Source: Reprinted from Toxicology In Vitro, Vol. 15, pp. 57-93, 2001, with permission from Elsevier Science (ScienceDirect TM http://www.sciencedirect.com)
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New Epidermal Model for Dermal Irritancy Testing
Published: January 1st, 1994 | Category: IIVS Publications
Source: Reprinted from Toxicology In Vitro, Vol. 8, No. 5, pp.889-891, 1994, with permission form Elsevier Sciences. (ScienceDirect TM http://www.sciencedirect.com)
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