The BCOP – protocol, performance and experience
Published: August 26th, 2005
by John Harbell (IIVS, USA) SOURCE
Practical Training Workshop on In Vitro Eye Irritation Methods, August 26, 2005,Berlin, Germany
SUMMARY
Practical Training Workshop on In Vitro Eye Irritation Methods
Co-sponsored by:
Institute for In Vitro Sciences, IIVS (Gaithersburg, USA),
Beiersdorf AG (Hamburg, Germany),
BfR-ZEBET (Berlin, Germany).
SCOPE: The Workshop aims at practical training in most frequently used in vitro methods for
prediction of eye irritation potential. Primary focus is a training in methods that have gained
regulatory acceptance for specific purposes in Europe, namely the Bovine Cornea Opacity
and Permeability Test (BCOP), the Chicken Enucleated Eye Test (CEET), the Isolated
Rabbit Eye Test (IRE) and the Hen’s Egg Test on the Chorio-Allantois Membrane (HETCAM).
In addition, as an example, the use of a reconstituted human corneal tissue model
will be demonstrated. For logistical reasons, only the HET-CAM training will be a real-life,
hands-on laboratory exercise, where participants perform the test, the outcome is beamed
on a screen, and discussed with all participants. The other assays will be covered with
technically orientated presentations given by experts routinely using these assays.
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