REPORT FROM AN IN VITRO DERMAL ABSORPTION ASSAY WORKSHOP
Published: August 21st, 2005
by Hans Raabe, Rodger Curren, Sherry Ward, John Harbell SOURCE
Presented at the 5th World Congress on Alternatives and Animal Use in Life Sciences, Berlin, Germany, August 21-25.
SUMMARY
The Institute for In Vitro Sciences (IIVS), Gaithersburg, Maryland, USA, hosted a workshop on in vitro
percutaneous absorption (PA) methods for a small group of international stakeholders in July 2005. The
purpose of the workshop was to provide a forum where stakeholders and method experts could come
together to discuss the various OECD-approved guidance on in vitro PA methods (OECD Test Guideline
428, April 2004; and Guidance Document for the Conduct of Skin Absorption Studies, March 2004) and how
this guidance may be practically applied to the protocols in current use. The workshop participants
compared and contrasted specific components of different in vitro protocols, and made recommendations on
protocol components that are essential for obtaining useful toxicological data from the in vitro PA methods. A
major goal of this workshop was to provide industry, contract research laboratories and the regulatory
community with practical information to facilitate successful, wider, and earlier use of in vitro PA data in
regulatory submissions. Detailed conclusions and recommendations from the workshop will be presented.
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