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What's New
New OECD In Vitro Skin Irritation Test Guideline Posted: August 12th, 2010
| OECD Test Guideline 439 — In Vitro Skin
Irritation: Reconstructed Human Epidermis
Test Method (TG 439) has been published.
TG 439 allows any of three reconstructed
human epidermis models (EpiSkin™,
EpiDerm™ SIT (EPI-200), and the SkinEthic™
RHE) to be used to classify materials as either
GHS 2 or non-irritant (UN GHS No Category). |
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The Latest Issue of the PASPCR Newsletter Now Available OnlinePosted: August 5th, 2010
| The latest issue of PanAmerican Society for Pigment Cell Research (PASPCR) is now available online. Dr. Gertrude-Emilia Costin, Study Director at IIVS, serves as Editor of the PanAmerican Society for Pigment Cell Research (PASPCR) Newsletter,which is published three times a year and is intended to serve as a regular means of communication for the members the Society. The August issue is available for review by clicking the link below. |
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IIVS Summer Newsletter Now AvailablePosted: August 4th, 2010
| The IIVS 2010 summer newsletter is now available. Please read the attached pdf document for information on TSCA reform, the 2010 In Vitro Alternatives Forum, the formation of a new scientific society, and much more. |
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In Vitro Vaginal Safety Screening Approach For Bath And Body Wash Products Utilizing Skinethic Human Vaginal Epithelium (HVE) Model Poster Presented at IUTOX MeetingPosted: August 4th, 2010
| A common goal of many personal care companies is to assure the safety of their products without animal testing, due to concerns about
ethical and animal welfare issues as well as the relevancy of the animal model to humans. To address these issues, we have developed an in vitro testing program to support the safety evaluation of potential vaginal irritation in a number of bath and shower cleanser products. A series of surfactant-containing formulations, diluted to 10% in water to mimic the maximum concentration expected in bath water, were tested. The formulations were applied topically onto the surface of commercially-available SkinEthic HVE three-dimensional human vaginal epithelium tissues over various exposure times. The ET50 (i.e. the exposure time expected to reduce relative viability of the tissues to 50%
of controls) for each candidate was determined. The test results were compared to reference formulations and available human clinical data. The vaginal irritancy evaluation and ranking of bath and body wash products based on ET50 values showed a good correlation with the expected irritation potential of individual ingredients. Histpathology confirmed the overall MTT viability results and provided additional information regarding the effect of the tested products on tissue integrity. However, IL-1α release did not appear to be as sensitive a marker as the MTT viability assessment at the short exposure times used (20 minutes, 1, 2, and 4 hours). This in vitro safety screening approach shows promise for predicting the vaginal irritancy of tested products and in meeting the typical needs of product development groups charged with developing increasingly milder products. |
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The predictive capacity of the 3T3 Neutral Red Uptake assay to identify substances LD with acute oral LD50 50 > kg> 2000 mg/kg poster presented at IUTOXPosted: August 4th, 2010
| The purpose of this validation study is to assess the capacity of the 3T3/NRU cytotoxicity assay to give a simple yes or no answer in order to discriminate between toxic/hazardous (LD50 < 2000 mg/kg) and not classified (LD50 >2000 mg/kg) substances. |
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Number of animal experiments performed in UK labs fallsPosted: August 2nd, 2010
| The number of scientific experiments carried out on animals in the UK dropped by 37,000 last year to just over 3.6m, according to data released by the Home Office. |
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