OECD Test Guideline 431 addresses the human health endpoint skin corrosion. It makes use of reconstructed human epidermis (RhE) (obtained from human derived non-transformed epidermal keratinocytes) which closely mimics the histological, morphological, biochemical and physiological properties of the upper parts of the human skin, i.e. the epidermis. This Test Guideline was originally adopted in 2004 and updated in 2013 to include a set of Performance Standards (PS) (Annex 1) for the assessment of similar and modified RhE-based test methods (8), in accordance with the principles of Guidance Document No. 34 (9). Other updates comprise the addition of two test methods, and the possibility to use some of the methods for the sub-categorisation among corrosive chemicals. Please follow the link above to read the full guideline, then contact us to speak to one of our study directors to determine how these updates could affect your testing program.