LLNA shown to overpredict sensitization potential in a recent weight-of-evidence evaluation of surfactants
An article written by a number of industry scientists and published in Regulatory Toxicology and Pharmacology evaluated eight surfactants in the local lymph node assay, guinea pig maximization test, and a number of in vitro assays.
A summary article indicated that "with one exception, the chemicals are non-sensitising skin irritants. However, one particular method, the local lymph node assay (LLNA), was shown to overestimate the sensitisation potential of surfactants relative to the other methods. The scientists conclude that, as results obtained from LLNAs are considered as the gold standard for the development of new nonanimal alternative test methods, there is a need to carefully evaluate the applicability domains of test methods in order to develop reliable non-animal alternative testing strategies for sensitisation testing."
To read more about skin sensitization testing available at IIVS, please review information on the KeratinoSens Assay for Skin Sensitization and contact Dr. Kimberly Norman, firstname.lastname@example.org, for more information.